Wisepowder e na le lisebelisoa tse fapaneng tsa ho tsofala le ho tsofala, 'me e na le sistimi e felletseng ea taolo ea boleng.

Ho bontša 1-4 ea liphetho tsa 13

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Botsofali le botsofali (Khahlano le botsofali)

Ho tsofala ke ntho eo bohle re e etsang empa re utloisisa hanyane ka eona. Boko ba hau bo ba le liphetoho ha u ntse u tsofala tse ka bang le litlamorao tse fokolang mohopolong oa hau kapa litsebo tsa ho nahana Ho bonolo ho etsa lethathamo la liphetoho tsohle tse tlisoang ke lilemo - tahlehelo ea mohopolo, makhopho, tahlehelo ea mesifa.
Ho tsofala (ho thibela-ho tsofala) e ka ba sehlooho se thata ho sebetsana le sona: ntoa e loanoa hona joale ka moelelo oa polelo ho lipatlisiso le meriana, hape e le sehlahisoa sa lihlahisoa tse matla le tse atisang ho qhekella.
Ho tsofala (Anti-botsofe) hona joale ho na le meelelo e fapaneng e fapaneng le meelelo e fapaneng.
- Thutong ea bo-ramahlale ba khahlanong le ho tsofala (ho tsofala) ho bolela feela ho liehisa, ho thibela kapa ho khutlisetsa morao botsofaling. Le ha bokamoso bo bonahala bo ts'episa haholo, ha joale ha ho na theknoloji ea bongaka e pakiloeng le e fumanehang e fokotsang kapa e khutlisang botsofali ho batho.
-Ka har'a khoebo ea bongaka le botumo bo botle, meriana e thibelang botsofali e bolela ho lemoha kapele, ho thibela le ho phekola mafu a amanang le lilemo. Sena se fapane hōle le ho sebetsana le ts'ebetso ea botsofali ka boeona, 'me hajoale ho na le maano a mangata le liphekolo. Mohlala kalafo ea Alzheimer's, lefu le amanang le botsofali.
Sebakeng se pharaletseng sa khoebo - se kenyelletsang likhoebo tse ngata tsa bomenemene kapa tse bobebe - ho loants'a botsofali ke lebitso la bohlokoa le mokhoa o bonts'itsoeng oa ho eketsa thekiso.

Kopo ea ho thibela botsofe

Ka mokhoa ona, lihlahisoa tse khahlanong le botsofali li ntse li eketseha le ho feta. Ts'ebetso ea phofo e tsofetseng e kenyelletsa:
- Lihlahisoa tsa tlhokomelo ea lihlahisoa
- Lihlahisoa tsa bophelo bo botle
-Oa seno
- Sehlahisoa sa lihlahisoa
Kalafo ea botsofe le Alzheimer's
Hoo e ka bang 3% ea batho ba pakeng tsa lilemo tse 65 le 74, 19% lipakeng tsa 75 le 84, mme halofo ea ba fetang lilemo tse 85 ba na le 'dementia'. mafu a lefu la Alzheimer, lefu la masapo, lefu la Parkinson le lefu la Lou Gehrig.
Botsofali ke sesosa se ka sehloohong sa kotsi ea lefu la Alzheimer's. Alzheimer's ke mofuta oa 'dementia' o bakang mathata mohopolong, menahanong le boits'oarong. Matšoao a Alzheimer hangata a hola butle mme a mpefala ha nako e ntse e tsamaea, a ba matla hoo a ka sitisang mesebetsi ea letsatsi le letsatsi. “Rea tseba hore lilemo ke lona lebaka le leholo le tlatsetsang ho Alzheimer's, ka hona ha ho makatse hore ebe re fumane sepheo sa lithethefatsi seo le sona se amanang le botsofali,”
FDA e boetse e amohetse joalo ka Namzaric, motsoako oa Namenda (memantine) le Aricept, bakeng sa kalafo ea tekano le lefu le matla la Alzheimer's.
Namendais (memantine) eo ho lumeloang hore e sebetsa ka ho laola glutamate, k'hemik'hale ea bohlokoa ea boko. Ha e hlahisoa ka bongata bo feteletseng, glutamate e ka lebisa lefung la boko. Hobane bahanyetsi ba NMDA ba sebetsa ka tsela e fapaneng le li-inhibitors tsa cholineterase, mefuta e 'meli ea lithethefatsi e ka khethoa hammoho.
Lihlahisoa tse ngata tse ncha li tsejoa li le molemo ho phekoleng lefu la Alzheimer's. Joalo ka phofo ea J-147, phofo ea CMS121.

Lihlahisoa tsa phofo tse thibelang botsofali

J-147 phofo (1146963-51-0): J147 ke ntho ea bophelo ba sejoale-joale, ho bonts'itsoe hore e phekola lefu la Alzheimer le ho felisa botsofali litoeba mme e se e loketse liteko tsa bongaka bathong. Sehlopha se se se ntse se etsa lithuto tse ling ka limolek'hule tse fetotsoeng ke phello ea J147 ho mitochondrial ATP synthase-eo ka boeona e ka bang liphofu tse ncha tsa lithethefatsi. J147 e phethile tlhahlobo e hlokahalang ea FDA ea liphoofolo.
Alpha-lipoic acid e phofo (1077-28-7): Alpha-lipoic acid ke khemikhale e kang vithamine e bitsoang antioxidant, e bolelang hore e ka fana ka tšireletso bokong tlasa maemo a tšenyo kapa kotsi.
Alpha-lipoic acid e bonahala e thusa ho thibela mefuta e itseng ea tšenyo ea lisele 'meleng, hape e khutlisa maemo a vithamine a joaloka vithamine E le vithamine C. Ho boetse ho na le bopaki ba hore alpha-lipoic acid e ka ntlafatsa ts'ebetso le tlhahiso ea li-neurons ho lefu la tsoekere.
Ho lahleheloa ke mohopolo ke taba e tloaelehileng har'a batho ba baholo. Ho lumeloa hore tšenyo e bakoang ke khatello ea maikutlo e nang le oxidative e bapala karolo ea bohlokoa molemong oa ho lebala.
Hobane alpha-lipoic acid ke antioxidant e matla, liphuputso li hlahlobile bokhoni ba eona ba ho fokotsa ts'ebetso ea mathata a khetholloang ke ho lahleheloa ke mohopolo, joalo ka lefu la Alzheimer's.
Mofuta, sebete, fig, sipin, broccoli le litapole ke mehloli e metle ea alpha-lipoic acid.
CMS121 phofo (1353224-53-9): Li-Geroprotectors ke lintho tse nang le monyetla oa ho fokotsa sekhahla seo phoofolo e tsofalang ka sona ka ho lebisa tlhokomelo botsofaling. Phuputso e ncha e hlahloba metsoako e mengata 'me e supa tse ling tse sireletsang methapo ea kutlo likotsing ka ho liehisa botsofali; bafuputsi ba reha metsoako ena geroneuroprotectors.
Ka ho sebelisa metsoako ena e le motheo, bafuputsi ba thehile lingaka tse tharo tsa lithethefatsi tsa Alzheimer's tse bitsoang CMS121, CAD31, le J147; ba sebelisitse fisetin le curcumin ka kotloloho. Sehlopha se bonts'itse hore metsoako eohle e mehlano e felisitse li-biomarker tsa botsofali, e eketsa nako ea litoeba le lintsintsi, 'me e fokotsa mats'oao a dementia.

Ketsahalo ea botsofali

Ho tsofala ke tšusumetso ea nako 'meleng oa motho,' me e etsahala maemong a mangata:
-Khale ea botsofali. Lisele tsa lilemo li ipapisitse le makhetlo ao ba a phetang. Sele e khona ho ikatisa makhetlo a ka bang 50 pele lihlahisoa tsa liphatsa tsa lefutso li se li sa khone ho hatisoa ka nepo, e leng ka lebaka la li-telomeres tse khutsufalitsoeng. Tšenyo e eketsehileng e etsoang liseleng ke li-radicals tsa mahala le lintlha tse ling, lisele tse eketsehileng li hloka ho ikatisa.
Ho tsofala. Lihormone li bapala karolo e kholo ea botsofaling, haholoholo nakong ea kholo ea bongoana le khōlo ea bocha. Litekanyetso tsa Hormone lia fetoha bophelong. Ho kena bohlankaneng ho tlisa makhopho a maholo le a maholo. Ha re ntse re tsofala, liphetoho tsa lihormone li lebisa letlalong le omileng le ho emeng.
Tšenyo e kholo. Tšenyo e bokelletsoeng e kantle kaofela. Ho pepesetsoa ke chefo, letsatsi, lijo tse kotsi, tšilafalo le mosi li baka 'mele. Ha nako e ntse e tsamaea, lintho tsena tse ka ntle li ka baka tšenyo ea lisele mme 'mele o oela kamorao ho matla a ona a ho hlokomela le ho lokisa lisele, lisele le litho tsa' mele.
Bofebe ba -Metabolic. Ha u ntse u tsoela pele ka letsatsi la hau, lisele tsa hau li lula li fetola lijo matla, tse hlahisang lintho tse ka ba kotsi. Ts'ebetso ea metabolizing le ho theha matla e baka tšenyo 'meleng ha nako e ntse e feta. Ba bang ba lumela hore ho liehisa ts'ebetso ea metabolic ka mekhoa e kang thibelo ea khalori ho ka lieha ho tsofala ho batho.
Matšoao a tloaelehileng a boitšoaro ba Alzheimer a kenyelletsa ho hloka boroko, ho lelera, ho ruruha, ho tšoenyeha, ho ba mabifi, ho hloka phomolo le khatello ea maikutlo. Bo-rasaense ba ntse ba ithuta hore na ke hobane'ng ha matšoao ana a hlaha ebile ba ithuta kalafo e ncha — lithethefatsi le nondrug — ho li laola.

Tlhaloso:

  1. Mortimer RK, Johnston JR (1959). "Nako ea bophelo ea Motho ka Mong Lisele tsa Tomoso". Tlhaho. 183 (4677): 1751-1752. Khoutu ea Libibele: 1959Natur.183.1751M. doi: 10.1038 / 1831751a0. hdl: 2027 / mdp.39015078535278. PMID 13666896
  2. Tlhahlobo ea liteko tsa liteko tsa lefu la Alzheimer e bonts'a litlamorao tse khahlano le botsofali ”(Press release). Salk Setsi. La 12 Pulungoana 2015. E khutlisitsoe ka la 13 Pulungoana 2015.
  3. Bafuputsi ba supa sepheo sa limolek'hule sa J147, se haufi le liteko tsa bongaka ho alafa lefu la Alzheimer's ". E khutlisitsoe 2018-01-30.
  4. Khokahano ea Mafu a Alzheimer Liphetoho tsa Neuropathologic le Boemo ba Temoho: Tlhahlobo ea Lingoliloeng Peter T. Nelson, Irina Alafuzoff, Eileen H. Bigio, Constantin Bouras, Heiko Braak, Nigel J. Cairns, Rudolph J. Castellani, Barbara J. Crain, Peter Davies, Kelly Del Tredici, Charles Duyckaerts, Matthew P. Frosch, Vahram Haroutunian, Patrick R. Hof, Christine M. Hulette, Bradley T. Hyman, Takeshi Iwatsubo, Kurt A. Jellinger, Gregory A. Jicha, Enikö Kövari, Walter A Kukull, James B. Leverenz, Seth Love, Ian R. Mackenzie, David M. Mann, Eliezer Masliah, Ann C. McKee, Thomas J. Montine, John C. Morris, Julie A. Schneider, Joshua A. Sonnen, Dietmar. R. Thal, John Q. Trojanowski, Juan C. Troncoso, Thomas Wisniewski, Randall L. Woltjer, Thomas G. Beach J Neuropathol Exp Neurol. Sengoli se ngotsoeng ka letsoho; e fumaneha ka PMC 2013 Jan 30. E phatlalalitsoe ka foromo e hlophisitsoeng ea ho qetela e le: J Neuropathol Exp Neurol. 2012 Motšeanong; 71 (5): 362--381. doi: 10.1097 / NEN.0b013e31825018f7