Urolithin A phofo 1143-70-0

Tlhahisoleseling ea Urolithin A Powder

lebitso	Urolithin Phofo
CAS	1143-70-0
Ho hloeka	98%
Lebitso la k'hemik'hale	3,8-Dihydroxybenzo [c] chromen-6-ngoe
Li-synonyms	3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ngoe; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-e le 'ngoe; Pente ea Castoreum I; Urolithin A; 6H-Dibenzo (B, D) pyran-6-e le 'ngoe, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-ngoe); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ngoe
Molecular Formula	C13H8O4
Boima ba 'mele	228.2
Melting Point	> 300 ° C
InChI Key	RIUPLDUFZCXCHM-UHFFFAOYSA-N
foromo	E tiile
Ponahalo	Phofo e khanyang e khanyang
Halofo ea bophelo
Solubility	Soluble ho DMSO (3 mg / mL).
Boemo Storage	E omme, e lefifi ebile e le 0 - 4 C ka nako e khuts'oane (matsatsi ho isa ho libeke) kapa -20 C nako e telele (likhoeli ho isa ho lilemo).
kopo	Urolithin A ke metabolite ea ellagitannin; Lingoli tsa Bongaka
Tokomane ea Teko	fumaneha

 

Urolithin A phofo 1143-70-0 Tlhaloso e Khethehileng

Urolithin A phofo ke motsoako oa metabolite o bakoang ke phetoho ea li-ellagitannins ke libaktheria tsa mala mme ke sesosa sa mitophagy. Urolithin A e fetola mitochondria ho tloha ho CI- ho ea ho phefumoloho e tsamaisoang ke CII, e eketsa nako ea bophelo le ho ntlafatsa ts'ebetso ea mesifa. Ke ea sehlopha sa metsoako ea manyolo e tsejoang ka hore ke benzo-coumarin kapa dibenzo-α-pyrones. Li-precursors tsa eona - li-ellagic acid le li-ellagitannins - li fumaneha ka tlhaho, ho kenyeletsoa le limela tse jeoang, joalo ka likharenate, fragole, tse tala le walnuts. Ho tloha lilemong tsa bo-2000, urolithin A esale e le tlasa lithuto tsa pele mabapi le litlamorao tsa eona tsa bioloji.

Urolithin A phofo e ka ntlafatsa boleng le ts'ebetso ea mitochondria, mme ea eketsa matla le mamello ea mesifa ea botsofali. Ke eona feela sehlahisoa sa tlhaho se netefalitsoeng hore se qala bocha mitochondrial autophagy le ho khutlisa botsofe ba mesifa.

Li-Urolithin ke microflora metabolites ea batho ea lihlahisoa tsa acid tse ellagic, tse kang ellagitannins. Li hlahisoa ka har'a

mala a motho, 'me a fumanoa morong ka mokhoa oa urolithin B glucuronide kamora ho monya lijo tse nang le ellagitannins joalo ka

kharenate, fragole, tse tala tse khubelu, walnuts kapa veine e khubelu ea khale ea oak.

Nakong ea mala a mala ka libaktheria, li-ellagitannins le li-punicalagins li fetoloa ho li-urolithin, tse sa tsejoeng

ts'ebetso ea likokoana-hloko ka vivo bathong. Li-Urolithins metabolites tsa lero la kharenate ellagitannins li fumaneha ka ho khetheha ho

tšoelesa ea senya, mala le lisele tsa mala tsa litoeba.

Ellagitannins e hlahisa bioavailability e tlase mme e fetoloa ka maleng ho ea ho ellagic acid le microbiota metabolites ea eona.

Li-Urolithin li fumanoa ka lero la mali hangata e le li-glucuronides maemong a tlase.

Tlhahiso ea li-Urolithin e ipapisitse le mofuta oa enterosis oa microbiome. Batho ba hlahisang li-urolithin ba bonts'a bongata bo phahameng haholo

ea sehlopha sa Clostridium leptum sa Firmicutes phylum ho feta Bacteroides kapa Prevotella

 

Urolithin A phofo 1143-70-0 History

Lithutong tsa laboratori, urolithin A phofo e bontšitsoe ho hlohlelletsa mitophagy, e leng khetho e khethiloeng ea mitochondria ka autophagy, ts'ebetso e hloekisang mitochondria e senyehileng kamora tšenyo kapa khatello ea maikutlo, mme e se e sa sebetse hantle nakong ea botsofali. [14] Phello ena e bonoe mefuteng e fapaneng ea liphoofolo (lisele tsa mammalian, litoeba le C. elegans).

 

Urolithin A Powder 1143-70-0 Kopo

Urolithin A phofo e etselitsoe hore e sebelisoe e le sesebelisoa sa lijo tse khethiloeng kapa bakeng sa tšebeliso e khethehileng ea lijo lijong tse nkeloang lijong tse ipapisitseng le ts'ebetso ea eona ea phepo ho ts'ehetsa bophelo bo botle ba mitochondrial.

 

Urolithin A Powder 1143-70-0 Lipatlisiso tse ling

Urolithin A ha e tsejoe hore e ka fumaneha lijong life kapa life. E hlaha joalo ka lebaka la phetoho ea li-ellagic acid le ellagitannins ke mala a microflora bathong. Ellagic acid ka boeona e tsoa ho hydrolysis ea ellagitannins ka mpeng moo metsi a leng teng.

Mehloli ea li-ellagitannins ke: likharenate, linate, monokotšoai o mong (tse tala, fragole, monokotšoai, lehloa), tee, morara oa muscadine, litholoana tse ngata tsa tropike, le veine tse nang le lifate tsa oak (tafoleng e ka tlase).

Phetoho ea li-ellagic acid ho urolithin A ho latela sebopeho sa microflora ka bomong mme e ka fapana haholo.

 

Tšupiso ea Urolithin A Powder 1143-70-0

1. Paller CJ, Pantuck A, Carducci MA. Tlhahlobo ea kharenate ka mofetše oa senya. Kankere ea Prostate Dis. 2017 Mantaha 25. doi: 10.1038 / pcan.2017.19. [Epub pele ho khatiso] Tlhahlobo. E fetotsoe PMID: 28440320.
2. Ito H. Metabolites ea ellagitannin geraniin le mesebetsi ea bona ea antioxidant. Planta Med. 2011 Jul; 77 (11): 1110-5. doi: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Tlhahlobo. E fetotsoe PMID: 21294073.
3. Ishimoto H, et al. Ho vivo anti-inflammatory le antioxidant thepa ea ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Mphalane 1; 21 (19): 5901-4.