Emoxypine phofo (2364-75-2)

Emoxypine phofo (2364-75-2) video

 

Tlhahisoleseling ea Base ea Emoxypine powder

lebitso	Emoxypine phofo
CAS	2364-75-2
Ho hloeka	98%
Lebitso la k'hemik'hale	Mexicoidol; Mexicoifin
Li-synonyms	Emoxipine, Emoxypin, Epigid, 6-Methyl-2-ethyl-3-hydroxypyridine
Molecular Formula	C8H11NO
Boima ba 'mele	137.179 g g / mol
Melting Point	170 ho 172 ° C
InChI Key	JPGDYIGSCHWQCC-UHFFFAOYSA-N
foromo	tiileng
Ponahalo	E tšoeu ho Off-white poda
Halofo ea bophelo	Lihora tse 2-2.6
Solubility	Qhibilihang haholo ka metsing; DMSO (Hanyane ka hanyane); Methanol (Hanyane)
Boemo Storage	0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli).
kopo	RAD140 ke lipatlisiso le non-steroidal khetha androgen receptor modulator (SARM) bakeng sa kalafo ea maemo a kang ho senyeha ha mesifa le mofetše oa matsoele.
Tokomane ea Teko	fumaneha

 

Tlhaloso e akaretsang ea Emoxypine

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine) phofo, eo hape e tsejoang e le Mexicoidol kapa Mexicoifin ha e sebelisoa e le letsoai le matla, ke antioxidant e entsoeng Russiaby Pharmasoft Pharmaceuticals. Metsoako ea eona ea lik'hemik'hale e tšoana le ea pyridoxine (mofuta oa vithamine B6).

 

Nalane ea Emoxypine (2364-75-2) Nalane

Emoxypine phofo e qaliloe ka lekhetlo la pele ke LD Smirnov le KM Dumayev, ea ntan'o ithuta le ho nts'etsapelea ho Institute of Pharmacology, Russian Academy of Medical Science le Setsi sa Naha saense sa Pholohelo ea Bioactive.

 

Emoxypine (2364-75-2) Mokhoa oa ts'ebetso

Mefuta ea ts'ebetso ea Emoxypine ho lumeloa hore ke litlamorao tsa eona tsa antioxidant le membrane-sireletsang ka likarolo tse latelang tsa bohlokoa:

• Emoxypine inhibits oxidation ea mahala ea biomembrane lipids, e kopana le radicals ea lipilisi tsa lipids tsa mantlha le hydroxyl e matla ea peptides
• E eketsa ts'ebetso ea li-enzyme tsa antioxidant, haholo-holo tse bakoang ke superoxide dismutase, e ikarabellang ho theheng le tšebeliso ea lipid peroxides le mefuta e sebetsang ea oksijene
• Inhibits li-radicals tsa mahala nakong ea karolelano ea prostaglandin e koetliselitsoeng cycloo oxygenase le lipo oxygenase, e eketsa mokhoa oa ho kopanya prostacyclin / thromboxane A2and e thibela sebopeho sa leukotriene
• E eketsa litaba tsa karoloana ea polar ea lipids (phosphatidyl serine le phosphatidyl inositol) le ho fokotsa sekhahla sa cholesterol / phospholipids se bontšang thepa ea methapo ea lipid; liphetoho tsa sebopeho libakeng tse mocheso o tlase, e leng se nyopisang phokotso ea sebopeho sa membrane le keketseho ea ho phalla ha eona, e eketsa tekanyo ea lipid-protein.
• E fetola tšebetso ea li-enzyme tse tlameletsoeng kahara membrane: phosphodiesterase, cyclicnucleotides, adenylate cyclase, aldoreductase, acetylcholinesterase.
• Modulates li-receptor li-membrane tsa bokong, joalo ka benzodiazepine, GABA, li-receptor tsa acetylcholine ka ho eketsa bokhoni ba tsona ba ho kopanya.
• E tsitsisa li-biomembranes, ke hore, likarolo tsa lisele tsa mali - li-erythrocyte le li-thrombocyte nakong ea haemolysis kapa kotsi ea bona ea mochini e tsamaeang le sebopeho sa li-radicals tsa mahala.
• E fetola sekhahla sa monoamine mme e eketsa dikahare tsa dopamine bokong.

Sesebelisoa sa Emoxypine (2364-75-2) Sesebelisoa

Naheng ea Russia, emoxypine e na le likopo tse ngata tse fapaneng tšebetsong ea bongaka. E ikoetlisa ka mokhoa o hlakileng, khatello ea khatello ea maikutlo, anti-joala, anticonvulsant, nootropic, neuroprotective le anti-inflammatory action. Emoxypine ka mohlomong e ntlafatsa phallo ea mali a khubung, e thibela ho kopana ha mali, ho fokotsa maemo a k'holeseterole, a na le tšebetso ea pelo le pherekano.

 

Emoxypine (2364-75-2) Patlisiso e Eketsehileng

Phuputso e 'ngoe e bontšitse katleho ea emoxypine ho bakuli ba 205 ba nang le lipontšo tsa kliniki ea lumbosacral radiculopathy (LSR). Bakuli ba ile ba aroloa ka lihlopha tse peli, 'me ho ea pele ba ile ba aroloa lihlopha tse nyane ho latela boteng ba likotsi tsa makoloi. Bakuli bohle ba ile ba fumana koetliso ea kalafo e tloaelehileng le physiotherapy; sehlopha sa mantlha se ile sa amohela emoxypine hape. Kamora moo, taolo ea methapo ea methapo ea kutlo le liphetho tsa nako e telele tsa kalafo lihlopheng tse ling tsa bakuli li ile tsa etsoa. Liphetho li bonts'itse hore ts'ebeliso ea emoxypine kalafong e kopaneng ea bakuli ba nang le LSR e lebisitse phokotsong ea bohlokoa le e tsoelang pele ea ts'ebetso ea methapo ea bohloko le ho hlaphoheloa kapele hoa ts'ebetso ea metso ea lesapo la mokokotlo le methapo ea kutlo e bapisoang le kalafo e tloaelehileng.

 

Emoxypine (2364-75-2) Buka

[1] Dumayev KM, Voronina TA, li-antioxidants tsa smirnov LD ka har'a prophylaxis le kalafo ea li-pathologies tsa CNS. Moscow, 1995

[2] Kucheryanu, VG (Pherekhong 2001). "Mexidol e ka matlafatsa tšebetso ea antiparkinsonia ea L-DOPA ka mofuta oa parkinsonism oa MPTP". Eksperimental'naia i klinicheskaia farmakologiia. EA-64 (1): 22-25.

[3] Likhacheva, EB; Sholomov, II (2006). "Tlhatlhobo ea bongaka le boits'oaro ba mmele ea katleho ea mexidol kalafo ea lumbosacral radiculopathy". ZhurnalNevrologii i Psikhiatrii Imeni SS Korsakova. 106 (10): 52-7.