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Hydrafinil (9-Fluorenol) phofo (1689-64-1)

Hydrafinil (9-Fluorenol) (1689-64-1)

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Hydrafinil (9-Fluorenol) phofo (1689-64-1)

Hydrafinil (9-Fluorenol) phofo ke joala bo tsoang ho fluorene. Ho isomer ea bohlokoa ka ho fetisisa, fluoren-9-ol kapa 9-hydroxyfluorene, sehlopha sa hydroxy se teng khabone e patisanang pakeng tsa mehele e 'meli ea benzene. Hydrafinil (9-Fluorenol) e ka fetoloa fluorenone ka oxidation. Ke 'mala o mosoeu o nang le' mala o mosoeu ka holim'a mocheso oa kamore.

Etsa: Batch Production

sephutheloana: 1KG / mokotla, 25KG / moqomo

Category: Nootropics phofo

Tlhaloso

Hydrafinil (9-Fluorenol) phofo (1689-64-1) video

Tlhahisoleseling ea Hydrafinil (9-Fluorenol)

lebitso	Hydrafinil (9-Fluorenol) phofo
CAS	1689-64-1
Ho hloeka	98%
Lebitso la k'hemik'hale	hydrafinil;Hydranafil;9-FLUORENOL;fluoren-9-ol;Hydroxyfluoren;9h-fluoren-9-ol;Fluoren-9-ol 97%;9-HYDROXYFLUORENE;9-HYDROXY-FLUOREN;9-Fluorenol, 98+%
Li-synonyms	9-Hydroxy fluorene
Molecular Formula	C13H10O
Boima ba 'mele	182.22 g / mol
Melting Point	152-155 ° C
InChI Key	AFMVESZOYKHDBJ-UHFFFAOYSA-N
foromo	tiileng
Ponahalo	Kristale e soeufalitsoeng
Halofo ea bophelo	6 ho lihora tsa 8
Solubility	Chloroform (Hanyane ka hanyane), Methanol (Nyenyane)
Boemo Storage	Sehatsetsi
kopo	E sebelisoa meriana, lihlahisoa tsa bophelo bo botle, lijo, seno, litlolo, likokoana-hloko le lik'hemik'hale tsa lik'hemik'hale le liindasteri tse ling.
Tokomane ea Teko	fumaneha

Tlhaloso e akaretsang ea Hydrafinil (9-Fluorenol)

Hydrafinil (9-Fluorenol) phofo ke joala bo tsoang ho fluorene. Ho isomer ea bohlokoa ka ho fetisisa, fluoren-9-ol kapa 9-hydroxyfluorene, sehlopha sa hydroxy se teng khabone e patisanang pakeng tsa mehele e 'meli ea benzene. Hydroxy fluorene e ka fetoloa ho Hydrafinil (9-Fluorenol) ka oxidation. Ke 'mala o mosoeu o nang le' mala o mosoeu ka holim'a mocheso oa kamore.

Hydrafinil (9-Fluorenol) phofo e tsoa ho fluorene mme e ntse e khotsofatsoa joalo ka karolo ea eugeroic, e khothaletsang ho tsoha. Khamphani Cephalon e fuputse Hydrafinil (9-Fluorenol) ha e bapisoa le eugeroic drug modafinil. Patlisisong ea bona ea papiso le litoeba, ba hlokometse hore Hydrafinil (9-Fluorenol) e ne e sebetsa hantle haholo ho feta modafinil (ho fihlela 39%). Le ha e na le thepa ea dopamine reuptake, hangata e ea fokola.

Nalane ea Hydrafinil (9-Fluorenol) phofo

Hydrafinil (9-Fluorenol) phofo ke k'hemik'hale ea lipatlisiso e sa laoloang e neng e entsoe ke Cephalon Pharmaceuticals (eo joale e leng ea Teva) joalo ka eugeroic (moemeli ea khothalletsang ho tsoha). Kamora ho qaptjoa ha eona, Hydrafinil (9-Fluorenol) e bile e mong oa baemeli ba 'maloa ba lokelang ho nkuoa e le mohlahlami oa khopolo ea sethethefatsi se tsebahalang le se amoheloang ke FDA, Provigil (Modafinil). Lintlha tse bapisoang le liteko tsa liphoofolo li bonts'a hore Hydrafinil (9-Fluorenol) e bonts'itse ~ 39% ts'ebetso e kholo ea eugeroic ho feta modafinil ka nako e khuts'oane (hora ea 4).

Leha ho le joalo, ka mabaka a sa tsejoeng, Cephalon o ile a hlakola nts'etsopele ea Hydrafinil (9-Fluorenol) joalo ka eugeroic ea lipale tse ka bang teng. Sebakeng seo, ba laetse boiteko le lisebelisoa ho etsa lipatlisiso, ho nts'etsapele le ho bapatsa lithethefatsi armodafinil. Armodafinil (e rekisoang tlasa lebitso la "Nuvigil") e ne e tla tsejoa e le mohlahlami oa semmuso oa meriana ho Provigil, e siea ba bangata ba ipotsa hore na ebe Hydrafinil (9-Fluorenol) ekaba tsoelo-pele e phahameng.

Ba bang ba hakanya hore ts'ebeliso ea pele ea Hydrafinil (9-Fluorenol) e le sebolaya likokonyana ho ella bofelong ba lilemo tsa bo-1930, chefo e netefalitsoeng ho liphoofolo tse hlaha tsa metsing, le tokelo ea molao ea Cephalon e ka bang lebaka la ho emisa nts'etsopele ea eona. Ho tloha ka 2015, Hydrafinil (9-Fluorenol) e boetse e tumme har'a batho ba chesehelang li-nootropic mme joale e se e rekisoa e le ntho e sa laoloang inthaneteng tlasa lebitso la "Hydrafinil." Batho ba bangata ba itlhahloba ba netefatsa hore e sebetsa hantle, empa ba bang ba belaella lipolelo tsena 'me ba hlokometse boemo ba eona bo se nang litokomane.

Mechanism ea ts'ebetso ea Hydrafinil (9-Fluorenol)

Mechini ea ts'ebetso e amanang le hydrafinil ha e hlake hantle. Ba bangata ba nahana hore e sebetsa joalo ka mohanyetsi oa 5-HT6 ea amohelang le e sa tsotelleng ea dopamine reuptake inhibitor (DRI). Hore na likhopolo-taba tsena li nepahetse hoa nepahala kaha ha e so ka e batlisisoa ka semolao bathong. Ho sa tsotelehe, hydrafinil e kanna ea matlafatsa ho ba le kelello le ts'ebetso ea ts'ebeliso ea kelello haholoholo ka phetiso ea phetisetso ea dopaminergic le noradrenergic.

Kopo ea Hydrafinil (9-Fluorenol)

9-Fluorenol e boetse e tsejoa e le hydrafinil 'me ke moloko o latelang oa likhothaletso tse lemohileng tse 39 nileng tsa sebetsa ho feta modafinil ho boloka tlhokomeliso. E na le ts'ebetso ea ts'ebetso ea "modafinil" ka mokhoa o atlehileng joaloka modafinil, mme ha e na lipuisano tse tšoanang le modafinil. Hape ha e lule nako e telele, ho etsa hore ho be bonolo ho nka tekanyetso ka botlalo, ntle le ho emela litlamorao tsa lihora tse 140

Hydrafinil (9-fluorenol) ha e lemalle

Hydrafinil (9-Fluorenol) ke oa sehlopha sa lithethefatsi tse tsejoang e le Eugeroics. Tsena ke lintho tse matlafatsang tse tsohelang mohopolo o molelele oa kelello o lebisang ho tsoheng. Morero o hlahisang lithethefatsi tsena ke ho ntlafatsa tlhokomeliso ntle le ho tsosa litlamorao tsa 'mele kapa ho hlahisa tlhekefetso / ho mamella / tšibollo ea litlatsetso tse tloaelehileng. Mme Hydrafinil (9-Fluorenol) ha e tšoane.

Ts'usumetso ea Hydrafinil ea dopamine pathways ha e bohlokoa haholo ho feta modafinil's e bolelang hore ha e na monyetla oa ho e lemalla.

Hydrafinil (9-fluorenol) ha e na kankere ebile e na le chefo ho batho

Setlhare sena ke joala bo tsoang ho fluorine. Sehlopha sa eona sa hydroxyl se behiloe pakeng tsa mehele ea eona e 'meli ea benzene khabong ea marokho. Ts'ebetso ea oksidi e ka sebelisoa ho fetola hydroxyfluorene hore e be fluorenone. K'hemik'hale ena ha e na carcinogenic hape ha e kotsi ho batho. Kahoo, thuto e ile ea etsoa ke Barekisi ba sebetsang bakeng sa Cephalon (k'hamphani ea meriana ea bio), ka mokhoa o hlakileng ba tla ba le moriana o neng o tla atleha Modafinil, e leng sethethefatsi se khahlanong le narcolepsy.

Hape ha e lule nako e telele, ho etsa hore ho be bonolo ho nka tekanyetso ka botlalo, ntle le ho emela litlamorao tsa lihora tse 12. E na le li-affinities tsa DAT tse tlase hanyane empa li ne li e-na le liketso tse phahameng tsa eugeroic. E matla haholo ho feta modafinil e nang le 50-100mg e lekanang le 100-200mg bakeng sa modafinil. Ha e bonye chefo ebile ha ho na litšebelisano tsa sebete.

Hydrafinil (9-Fluorenol) Patlisiso e ngoe hape

Hydrafinil (9-Fluorenol) e chefo ho lintho tse phelang metsing ho kenyeletsoa bolele, libaktheria le li-crustaceans. Hydrafinil (9-Fluorenol) e ne e entsoe ka semolao e le sebolayaditshenekegi ka 1939, mme ke algaecide khahlano le bolele bo botala Dunaliella bioculata.

Ho na le chefo ea eona le pherekano ea batho ho batho ha e tsejoe.

Phuputso e phatlalalitsoeng ke bo-ramahlale ba sebeletsang k'hamphani ea biopharmaceutical Cephalon ho hlahisa mohlahlami ho eugeroic modafinil e tlaleha hore se tsoang ho Hydrafinil (9-Fluorenol) se ne se sebetsa ka 39% ho feta modafinil ho boloka litoeba li tsohile ka nako ea lihora tse 4. Ke dopamine reuptake inhibitor e fokolang e nang le IC50 ea 9 μM, haholo-holo 59% e fokolang ho feta modafinil (IC50 = 3.70 μM) leha e le eugeroic e matla, e ka e etsang hore e be le molato o monyane oa ho lemalla. E boetse e bonts'a ho se kopane ha cytochrome P450 2C19, ho fapana le modafinil.

Reference Hydrafinil (9-Fluorenol)

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