Fasoracetam phofo (110958-19-5)

Fasoracetam phofo (110958-19-5) video

 

Tlhahisoleseling ea Base ea Fasoracetam powder

lebitso	Pasoracetam phofo
CAS	110958-19-5
Ho hloeka	98%
Lebitso la k'hemik'hale	(R) -1 - ((5-Oxo-2-pyrrolidinyl) carbonyl) piperidine
Li-synonyms	Fasoracetam; N- (5-Oxo-D-prolyl) piperidine; NS-105; NFC-1; LAM-105.
Molecular Formula	C10H16N2O2
Boima ba 'mele	196.25 g / mol
Melting Point	57 ° C
InChI Key	GOWRRBABHQUJMX-MRVPVSSYSA-N
foromo	tiileng
Ponahalo	Pula e tšoeu
Halofo ea bophelo	dihora tse 1.5
Solubility	Ho qhibiliha ho DMSO
Boemo Storage	Boloka maemong a ommeng, a lefifi ho 0 - 4 ° C bakeng sa nako e khuts'oane (letsatsi / libeke), le - 20 ° C bakeng sa polokelo ea nako e telele.
kopo	Agonist ea li-receptors tsohle tse tharo tsa metabotropic glutamate receptors (mGluRs) ka ts'ebetso e ka bakang khatello ea maikutlo, e sebelisitsoeng litekong tsa bongaka tsa khatello ea methapo le khatello ea methapo.
Tokomane ea Teko	fumaneha

 

Tlhaloso e akaretsang ea Fasoracetam powder

Fasoracetam phofo (e tsejoang hape ka hore ke NS-105, LAM-105, le NFC-1) ke lithethefatsi tsa nootropic kapa tse bohlale tse tsoang lelapeng la racetam la lithethefatsi. E qalile pele ho hlaha lilemong tsa bo-1990 ke k'hamphani ea meriana ea Japane Nippon Shinyakune ka sepheo sa ho phekola 'dementia ea methapo. " Khamphani e sebelisitse li-fasoracetam tse fetang limilione tse 200 tsa moriana, leha ho le joalo, moriana o ile oa hloleha ho etsa liteko tsa bongaka tsa mophato oa pele ka lebaka la ho se sebetse 'me qetellong tsa lahloa.

Ka 2013, thahasello ho fasoracetam e ile ea tsosolosoa ha k'hamphani e bitsoang NeuroFi e reka lintlha tsa bongaka tsa lithethefatsi ho Nippon Shinyaku. NeuroFix hamorao e ile ea fumanoa ke Aevi Genomic Medicine, e qalileng liteko tsa bongaka ka 2016 ho bacha ba nang le ADHD, autism, kapa matšoenyeho, ba nang le liphetoho liphatseng tsa lefutso tsa glutamate receptor. Fasoracetam hajoale e se e le litekong tsa bongaka tsa mokhahlelo oa 2.

 

Nalane ea Fasoracetam phofo (110958-19-5) Nalane

Fasoracetam phofo e thehiloe ka 1990s ke k'hamphani ea meriana ea Japane Nippon Shinyaku e le kalafo e ka khonehang bakeng sa 'dementia ea methapo.' Nts'etsopele e ile ea emisoa kamora ho hlolisoa liteko tsa tleliniking, empa ka 2013, tlhaiso-leseling ea bongaka mabapi le fasoracetam (eo ka linako tse ling e hlalosoang ho lingoliloeng tsa lipatlisiso e le NS-105 kapa NFC-1) e rekiloe ke feme e thehiloeng ho US NeuroFix, mothusi oa Aevi Genomic Medicine.‍

Ka selemo sa 2015, phofo ea fasoracetam e amoheloe ke lenaneo la US la Tlhatlhobo e Ntle ea Tsamaiso ea Lithethefatsi, le fanang ka tumello ho baitlami ho qala liteko tsa tleliniki ea batho le ho romella lithethefatsi hohle mebusong ea naha.

Liteko tsa tleliniking ho fasoracetam li qalile hape ka selemo sa 2016, ho hlahloba monyetla oa potoloho ea kalafo ea Attention Deficit Hyperacaction Disorder (ADHD) baneng ba bonts'ang phetoho e itseng ea sistimi ea "glutamate receptor system" Adderall le tse ling tse hlahisoang ke amphetamine kalafo ea ADHD.‍

Ho ile ha rereloa tekano ea tlhahlobo ea mohopolo ea karolo ea II bakeng sa selemo sa 2018 ho etsa lipatlisiso tsa fasoracetam e le kalafo ea "Autism spectrum disorder" (ASD ).‍

Fasoracetam ha e so amoheloe ka molao bakeng sa tšebeliso efe kapa efe ke USFDA mme e thathamisitsoe e le k'hemik'hale ea lipatlisiso e sa reretsoeng ho sebelisoa ke batho.

 

Fasoracetam (110958-19-5) Mokhoa oa Ketso

Joalo ka li-racetams tsohle, mochini oa ts'ebetso oa fasoracetam ha o utloisisoe ka botlalo.

Lipatlisiso li bontšitse hore fasoracetam e sebetsa ka mekhoa e latelang:

Fasoracetam e eketsa ho lokolloa ha acetylcholine ho tsoa cortex ea motsoako. Acetylcholine ke neurotransmitter bokong bo ikarabellang bakeng sa ho hopola le ho ithuta. Fasoracetam e boetse e eketsa phepelo ea choline, motsoako o hlokahalang ho theha acetylcholine bokong bohle.

Fasoracetam e eketsa palo ea li-receptor (ka cortex) bakeng sa inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

E boetse e kenya tšebetsong mefuta e meng ea li-glutamate receptors (metabotropic glutamate receptors - mGluRs). Glutamate ke "neurotransmitter" e kholo ea thabo, 'me li-mGluR li na le mesebetsi e mengata ho pholletsa le boko [R, R].

 

Kopo ea Fasoracetam (110958-19-5)

(1) E kanna ea Thibela tahlehelo ea Memori

Likhoto, fasoracetam e ile ea thibela mathata a memori a bakoang ke baclofen, activator ea li-receptor tsa GABA-B. E boetse e fokotsa amnesia ka ho eketsa acetylcholine le ho fokotsa litlamorao tsa ts'ebetso ea GABA-B.

(2) E ka fokotsa matšoao a khatello ea maikutlo

Mefuta e sa tloaelehang ea GABA e amana le mathata a itseng a boko, ho kenyelletsa matšoenyeho le khatello ea maikutlo. Fasoracetam e fokotse matšoao a nyahamisang ho likhoto tse neng li fuoe mokhoa oa ho thusa ho qoba maemo a mabe (ho hloka thuso)

 

Fasoracetam (110958-19-5) Patlisiso e Eketsehileng

Fasoracetam phofo ke k'hemik'hale ea lipatlisiso ea lelapa la morabe. Ke putot noicrop e ileng ea sitoa ho bontša katleho e lekaneng litekong tsa bongaka tsa 'dementia ea methapo. Hona joale e ntse e ithutoa bakeng sa ts'ebeliso ea eona e ka bang teng bakeng sa tlhokomelo ea deficithyperactivity disorder.

Bo-rasaense ba Sepetleleng sa Bana sa Philadelphia se etelletsoeng pele ke Hakon Hakonarson ba ithutile ts'ebeliso e ka bang teng ea fasoracetam ho ela hloko bothata ba ho se sebetse hantle.

 

Fasoracetam (110958-19-5) Tšupiso

• Lithethefatsi tse kang Piracetam le piracetam: ho tloha ho saense ea mantlha ho isa lits'ebetsong tsa tliliniki ea likoluoa ​​ho isa ho mafu a CNS |
• Chugh G, Asghar M, Patki G, Bohat R, Jafri F, Allam F, Dao AT, Mowrey C, Alkadhi K, Salim S. Lijo tse nang le letsoai le phahameng le boetse le fokotseha ka linako tse amanang le ts'ebetso ea kelello, boits'oaro le pelo ho male Fischer brown Norway rats. J Nutr. 2013 Sep; 143 (9): 1406-13. doi: 10.3945 / jn.113.177980. Epub 2013 Jul 17. PubMed PMID: 23864508; PubMed Central PMCID: PMC3743272.
• LAM 105, NS 105. Lithethefatsi R D. 1999 Aug; 2 (2): 135-6. PubMed PMID: 10820660.
• Hirouchi M, Oka M, Itoh Y, Ukai Y, Kimura K. Karolo ea metabotropic glutamate receptor subclasses mochineng oa liketsahalo tsa adenylyl cyclase ke nootropic NS-105. Eur J Pharmacol. 2000 Jan 3; 387 (1): 9-17. PubMed PMID: 1063315
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