Phenethyl Caffeate phofo (104594-70-9)

Video ea Phenethyl Caffeate powder (104594-70-9) video

 

Tlhahisoleseling ea Phenethyl Caffeate powder Base

lebitso	Phenethyl caffeate phofo
CAS	104594-70-9
Ho hloeka	> 98.0% (HPLC)
Lebitso la k'hemik'hale	Caffeic acid e phenethyl ester Pfeethyl kefir 104594-70-9 CAPE Pfeylethyl kefir
Li-synonyms	3- (3,4-Dihydroxyphenyl) - est-propenoic acid phenylethyl ester
Molecular Formula	C17H16O4
Boima ba 'mele	284.311 g / mol
Melting Point	127.0-131.0 ° C
InChI Key	SWUARLUWKZWEBQ-VQHVLOKHSA-N
foromo	tiileng
Ponahalo	Pente e mosehla e khanyang
Halofo ea bophelo	21.2 ho metsotso ea 26.7
Solubility	Soluble ho DMSO (10 mg / ml), ethanol (100 mM), ethyl acetate (50 mg / ml), methanol, acetone le acetonitrile. Ha e na metsi.
Boemo Storage	-20 ° C
kopo	Moemeli oa antineoplastic Ntho e thibelang kapa e thibelang ho ata ha li-neoplasms. moemeli oa neuroprotective Ntho e 'ngoe le e' ngoe e ka sebelisetsoang kalafo ea methapo ea methapo. anti-inflammatory K'holera efe kapa efe e nang le litlamorao tse khahlanong le ho ruruha. immunomodulator Sesebelisoa sa bioloji se sebetsang se amang kapa se bapala karolo ea ts'ebetso ea sesole sa 'mele.
Tokomane ea Teko	fumaneha

 

Tlhaloso e akaretsang ea Phenethyl Caffeate

Phenethyl Caffeate phofo (104594-70-9) ke ester ea alkyl caffeate eo ho eona 2-phenylethyl e leng karolo ea alkyl. E na le karolo e le moemeli oa antineoplastic, moemeli oa anti-inflammatory, immunomodulator, metabolite, antioxidant, moemeli oa tšebetso ea methapo, moemeli oa antiviral le moemeli oa antibacterial.

Phofo ea caffeate ea Phenethyl ke motsoako oa joala oa feberu le motsoako o monate oa protheine ea mahe a linotsi, ka mesebetsi ea antineoplastic, cytoprotective le immunomodulating. Kamora ts'ebetso, Phenethyl caffeate e thibela ts'ebetso ea mongolo oa nyutlelie oa NF-kappa B mme e ka hatella litsela tsa ho saena tsa p70S6K le Akt. Ntle le moo, Phenethyl caffeate inhibits maseli a boreleli a masapo a PDGF ka ts'ebetso ea p38 mitogen-activated protein kinase (MAPK) le hypoxia-inducible factor (HIF) -1alpha le ho kenella ka morao ho heme oxygenase-1 (HO-1 ).

 

Nalane ea Phenethyl Caffeate ea phofo

Phenethyl caffeate ke motsoako o fumanoang propolis, motsoako o hlahisoang ke linotši. Phenethyl caffeate e bontša li-anti-inflammatory, anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity, le anticancer chemotherapeutic. In vitro, phenethyl caffeate e thibela polelo e susumetsoang ke IL-1β ea IL-6, MCP-1, le ICAM-1, hape e hatella phosphorylation ea Akt le NF-κB. Ho vivo, phenethyl caffeate e fokotsa maemo a AST le lactate dehydrogenase mme e hatella lipid peroxidation.

 

Phenethyl Caffeate Mechanism Of Ts'ebetso

Phenethyl caffeate ke karolo ea propolis ea mahe a linotši a linotši mme ho bonts'itsoe hore e na le litlamorao ho ts'ehetso ea papilloma ho litoeba. Boithuto bo bontšitse hore Phenethyl caffeate e sebetsa e le sesebelisoa se khahlanong le ho ata ha kholo ea lisele tse ngata. Ho bonts'oa hape hore Phenethyl caffeate e ka baka ho arohana ha DNA le apoptosis e ka bang le litholoana tse chefo ho lisele tsa clon rat embryo fibroblast (CREF). Ntle le moo, lisele tsa CREF tse felisitsoeng ke cellular glutathione (GSH) li ne li bonahala li ameha haholo ka lefu la sele e hlahisitsoeng ke Phenethyl caffeate.

Phenethyl caffeate e tlalehiloe e na le li-anti-carcinogenic, anti-inflammatory le immunomodulatory thepa. Phenethyl caffeate e boetse e thibela HIV-1 integrase. Ho nahanoa hore litšobotsi tse khahlanong le ho ruruha li bakoa ke ho hatella tsela ea lipoxygenase ea arachidonic acid metabolism ke Phenethyl caffeate. Boithuto bo boetse bo bontšitse Phenethyl caffeate hore e be inhibitor e ikhethileng le e matla ea ts'ebetso ea phetisetso ea nyutlelie NF kappa B, e leng rarahanyo ea protheine e laolang phetolelo ea DNA. Phenethyl caffeate ke inhibitor ea ODC le Tyrosine Kinase.

 

Kopo ea Phenethyl Caffeate

Phenethyl caffeate e boetse e fokotsa boima ba 'mele le mafura a mangata mefuteng ea liphoofolo a fepa lijo tse nang le mafura a mangata, ka tšitiso ka ho thibela adipogeneis. Mefuteng e meng ea liphoofolo, motsoako ona o thibela 5-lipo oxygenase mme o fokotse khatello ea mali, ho beoa ha collagen, le li-atomosselotic biomarkers tse ling. Mefuteng ea liphoofolo le ea cellular ea mofets'e oa colorectal, phenethyl caffeate induces apoptosis mme e thibela kholo ea cellular le tumor.

Moemeli oa antineoplastic

Ntho e thibelang kapa e thibelang ho ata ha li-neoplasms.

moemeli oa neuroprotective

Ntho e 'ngoe le e' ngoe e ka sebelisetsoang kalafo ea methapo ea methapo.

anti-inflammatory

K'holera efe kapa efe e nang le litlamorao tse khahlanong le ho ruruha.

immunomodulator

Sesebelisoa sa bioloji se sebetsang se amang kapa se bapala karolo ea ts'ebetso ea sesole sa 'mele.

 

Phenethyl Caffeate Patlisiso e ngoe hape

Phenethyl caffeate ke motsoako oa tlhaho oa lik'hemik'hale. Ke sona mofuta oa joala ba caffeic le joala ba phenethyl.

Phapang e kholo ea in vitro pharmacology le litlamorao mefuteng ea liphoofolo li tlalehiloe bakeng sa Pfeethyl caffeate, empa bohlokoa ba bona ba kliniki ha bo tsejoe. E na le thepa ea antimitogenic, anticarcinogenic, anti-inflammatory, and immunomodulatory in vitro. Phuputso e 'ngoe e boetse e bonts'itse hore Phenethyl caffeate e hatella likarabo tse matla tsa mmele tsa ho itšireletsa mafung le ho ruruha ka vitro. Tšusumetso ena e khahlanong le mofetše e boetse ea bonahala ha letlalo la litoeba le phekoloa ka linotsi tsa linotši 'me le pepesetsoa TPA, k'hemik'hale e hlohlelletsang papillomas ea letlalo. Pfeethyl caffeate haholo e fokolitse palo ea papillomas.

 

Reference Phenethyl Caffeate

Yang JW, Jung WK, Lee CM, et al. Caffeic acid phenethyl ester e thibela litlamorao tsa ho ruruha ha li-interleukin-1β ho li-fibroblasts tsa corneal tsa motho. Immunopharmacol Immunotoxicol. 2014 Oct; 36 (5): 371-7. PMID: 25151996.