Oleoylethanolamide (OEA): Lithethefatsi tse Laolang Boima Tse re thusang ho Laola Takatso ea Lijo

Oleoylethanolamide (OEA) ke eng?

Oleseng (OEA) ke taolo ea tlhaho ea boima, k'holeseterole le takatso ea lijo. Metabolite e hlophisitsoe ka bongata maling a manyane. Molek'hule ea tlhaho e ikarabella bakeng sa maikutlo a botlalo ka mor'a ho ja lijo. Oleoylethanolamide e thusa ho laola mafura a 'mele ka ho tlama Peroxisome proliferator-activated receptor alpha (PPAR-Alpha). Metabolite ena ea tlhaho e ntlafatsa metabolism ea mafura a 'mele mme e tsebisa boko ba hau hore o nkile lijo tse lekaneng mme o lokela ho emisa ho ja. Oleoylethanolamide hape e eketsa litšenyehelo tse sa amaneng le ho ikoetlisa tse amanang le khalori.

Oleoylethanolamide (OEA) e sebetsa joang?

Mokhoa oa ketso oa Oleoylethanolamide (OEA)

Boitšoaro bo botle (OEA) e sebetsa joaloka takatso ea taolo. Oleoylethanolamide e laola tšebeliso ea hau ea lijo ka ho romella lipontšo ho bokong ho e tsebisa hore o tletse, 'me ke nako ea ho khaotsa ho ja. Ka lebaka leo, o ja lijo tse fokolang letsatsi le leng le le leng, 'mele oa hau o emisa ho paka boima bo eketsehileng ka nako e telele.

Oleoylethanolamide (OEA) (111-58-0) e hlahisoa le ho bokelloa ka popelong e nyane ho tsoa ho oleic acid e tsoang lijong. Lijo tse nang le mafura a mangata li ka sitisa tlhahiso ea Oleoylethanolamide ka mpeng e nyane.

Oleoylethanolamide e theola tšebeliso ea lijo ka ho susumetsa ho potoloha ha histamine bokong, homeostatic oxytocin, le hedonic dopamine pathways. Ho totobetse hore Oleoylethanolamide e ka khona ho bonts'a matšoao a CB1R, ao haeba a hlohlelletsoa a ka lebisang keketseho ea lijo. Oleoylethanolamide e fokotsa lipalangoang tsa lipid ho li-adipocytes ho theola boima ba mafura.

OEA e boetse e sebetsa ho khothaletsa ho tsejoang e le PPAR mme ka nako e ts'oanang e theola ho boloka mafura le ho eketsa ho chesa mafura. Nako le nako ha o ja lijo, maemo a OEA a phahama mme takatso ea hau ea theoha. Sena se etsahala hobane methapo ea kutlo e hokahaneng le bokong ba hau e tsebisa hore u leboha ka botlalo PPAR-α. PPAR-α ke "receptor" ea nyutlelie e sebelisang matla a nyutlelie e kenyelletsoang tseleng ea homeostasis ea motlakase le polelo ea mofuta oa lipid metabolism.

Oleoylethanolamide (OEA) e bonts'a litšobotsi tsohle tse hlalosang satiety factor tse kenyeletsang:

• Ho thibela ho fepa ka ho eketsa nako ea nako pakeng tsa sejo se seng ho ea lijong tse latelang;
• Tlhahiso ea eona e laoloa ke ho fumaneha ha limatlafatsi
• Maemo a eona a fetoha ka linako tsa phapang ea circadian.

Melemo ea Oleoylethanolamide (OEA)

Melemo ea Oleoylethanolamide le litlamorao tsa ho theola boima ba 'mele li kenyeletsa;

i. Fokotsa takatso ea lijo e hlasimollang e tsejoang ka hore ke Ghrelin

Liente tsa Peripheral tsa OEA tse fuoeng litoeba tse neng li itime lijo ka letsatsi le le leng ha li a ama li-hormone tsa ghrelin ka nako ea metsotso e 120, empa kamora lihora tse 6 ho ile ha fokotseha ho makatsang ha hormone ena ka liperesente tse 40 ho isa ho tse 50. Leha ho le joalo, Oleoylethanolamide e ne e se na litlamorao ho tsepamiso ea maikutlo a takatso ena ea li-hormone litlamong tse fuoeng. Sena se fana ka maikutlo a hore tlatsetso ea OEA e sebetsa hantle haholo ho fokotsa maemo a ghrelin haeba a nooa pele ho lijo.

Ii. Ho eketsa sekhahla sa tahlehelo ea mafura a 'mele

Li-receptor tsa βeta-adrenergic li sebetsa ho matlafatsa boima ba 'mele le ho tsosa mohopolo oa βeta3-adrenergic receptor e etsa hore tlhahiso ea lijo e fokotsehe le ho eketseha ha mafura litlamong. Li-receptor li etsa joalo ka ho susumetsa protheine e sa hlonepheng ho kenyeletsa UCP1.

Ka lebaka leo, ts'ebelisano 'moho ea injection3 agonist le oleoylethanolamide peripheral ente e bonahala e sebetsa ho fokotsa ho ja ha lijo le ho sebetsa hantle ho theoleng boima ba mafura bo amanang le ho phahama ha tšebeliso ea matla. Ho phahama ha maemo a UCP1 le PPARcy (eo ho nahanoang hore e bonts'a tšebeliso ea tšebeliso ea matla) ho etsahetse linthong tse bosootho le tse tšoeu tsa adipose hammoho le lintlafatso tsa li-biomarker tsa mitochondrial.

Ka hona, OEA e bonahala e ntlafatsa litla-morao tsa sebopeho sa "metochondrial metabolism" le "thermogenic vitendo" ka litoeba ho li-tisy tse sootho le tse tšoeu tsa adipose, ka tekanyo e tšoanang ea oleoylethanolamide joalo ka e sebelisang ho laola takatso ea lijo.

Iii. Ho theola boemo ba Peptide YY (Homesone-e Hlahisang takatso)

Liente tsa 5mg / kg Oleoylethanolamide ho litoeba li bakile phokotso e itšetlehileng ka nako ea li-hormone peptide YY e hlahisoang ka maleng kahare ho naha e fepehileng le e haelloang ke lijo.

Na Oleoylethanolamide (OEA) Thuso ea Taolo ea Taolo?

Ho joalo. Oleoylethanolamide e tlatselletsang boima ba 'mele e thusa ho taolo ea takatso ea lijo ka ho kenya tšebetsong PPAR ka tsela ena e fokotsa ho boloka mafura le ho chesa mafura ka bongata. Ha o ja lijo tsa hau, maemo a Oleoylethanolamide a phahama le takatso ea hau ea takatso ea lijo ha li-signals li romelloa bokong ba hau li tsebisa boko hore o khotsofetse.

Ho bile le lithuto tse 'maloa tsa saense tse pakang phello ena. Ka mohlala, ka 2004, bafuputsi ba Danish ba ile ba ithuta litoeba tse neng li sa fuoe lijo ka letsatsi le le leng. Ba ba file OEA mme ba lemoha hore palo ea lijo tseo ba li nkang e theohile ka 15.5%. Ka mantsoe a bonolo, Oleoylethanolamide (OEA) o tima switjha ea tlala ho CNS (Central Nervous System).

Tekanyetso ea Oleoylethanolamide (OEA)

Mofuta o khothalletsoang oa oleoylethanolamide ke capsule e le 'ngoe ea 200mg ha e nkuoa ntle le motsoako. Ha e kopantsoe le lisebelisoa tse ling tsa tahlehelo ea boima ba 'mele, tekanyo ea OEA e lokela ho theoleloa pakeng tsa 100mg le 150mg.

Ho khothalletsoa hore o nke tlatsetso ea oleoylethanolamide metsotso e 30 pele ho lijo tsa hoseng kapa lijo tsa hoseng; o tla ikutloa o khotsofetse haholoanyane nakong ea lijo tsa hau ebe o qetella o nka lijo tse nyane.

Patlisiso e fana ka maikutlo a hore u ka fokotsa kapa u eketsa litekanyetso tsa letsatsi le letsatsi ho latela boima ba 'mele oa hau. Mohlala, haeba u le boima ba 150lb, u ka nka 100mg. Motho oa 200lb a ka nka 150mg mme motho ea 250lb a ka nka 180mg ea tlatsetso.

Litlamorao tsa Oleoylethanolamide (OEA)

Litla-morao tsa Oleoylethanolamide e ka ba tšoenyeho e kholo hara baetsi ba tlatsetso ba batlang ho kenyelletsa motsoako ona o matla sebopeho sa tahlehelo ea boima ba tlatsetso ea bona.

Kamora tlhahlobo e tebileng ea tlhaiso-leseling e fumanehang ea mahlale, US FDA (Tsamaiso ea Lijo le Lithethefatsi) e ne e sena litaba mabapi le polokeho ea molek'hule ena ea tlhaho. RiduZone e bile phofo ea pele ea OEA ho hlahisoa ka selemo sa 2015.

OEA ke oleic acid metabolite le karolo ea lijo tse phetseng hantle tsa letsatsi le letsatsi. Ho bolokehile ka botlalo ho nka tlatsetso ea Oleoylethanolamide kaha ha ho na litlamorao tse mpe tse tlalehiloeng ho fihlela joale.

Reka Oleoylethanolamide (OEA) Reka

U ka fumana oleoylethanolamide buy mabenkeleng a 'maloa a lithethefatsi tsa inthanete le' meleng. Leha ho le joalo o tla hloka ho ba hlokolosi kaha ha se barekisi bohle ba tšepahalang. Etsa bonnete ba hore u bala litlhahlobo tsa bonaoylethanolamide ho tseba hore na boiphihlelo ba bareki ba bona ba pele e ne e le bofe.

U ntse u ipotsa hore na oleoylethanolamide e rekisoa kae? Se ke oa tšoenyeha; u ka reka oleoylethanolamide marang-rang mona sebakeng sa rona sa marang-rang. Re ba botumo le boiphihlelo OEA mofani oa thepa mme re na le bokhoni ba ho fana ka Oleoylethanolamide (OEA) ho la USA le linaheng tse ling tse 'maloa ho pota lefatše. Ts'ebetso ea rona ea odara e bonolo empa e sireletsehile ka botlalo ebile e bolokehile Re boetse re tsamaisa lihlahisoa tsa rona ka liphutheloana tse tiisitsoeng hantle le tse ntle ho netefatsa polokeho le ho qoba tšilafalo efe kapa efe.

Sehlooho ka:

Ngaka Liang

Mothehi-motheo, boetapele ba tsamaiso ea mantlha ea k'hamphani; PhD e amohetse Univesithing ea Fudan ka k'hemistri ea manyolo. Ho ba le boiphihlelo bo fetang lilemo tse robong tšimong ea k'hemistri ea bongaka. Boiphihlelo bo ruileng ba k'hemistri e kopanyang, chemistry ea bongaka le tloaelo ea tloaelo le taolo ea merero

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