Nicotinamide Mononucleotide (NMN): Melemo, Tekanyetso, Tlatsetso, Patlisiso

Hobaneng ha re hloka Nikotinamide Mononucleotide (NMN)

Leha botsofe bo sa qojoe, ho na le tebello ea ho khutlisa ts'ebetso ena, rea leboha Nicotinamide Mononucleotide (NMN). Ho phela botsofaling bo butsoitseng ke toro ea motho e mong le e mong mme ho na le metsoako e joalo ka NMN e re thusang ho fihlela toro eo.

Kea tseba hore mohlomong u ntse u ipotsa hore na motsoako ona o amana joang le botsofali. Tšoara lithunya tsa hau hobane ke tla u tsamaisa ka melemo ea nicotinamide mononucleotide.

Nicotinamide Mononucleotide (NMN) ke selelekela sa NAD +. NAD + ke "biomarker ea bohlokoa" seleng ea motho. Ha re ntse re tsoela pele lilemong, k'hemik'hale ena e fokotseha ka lebaka la mesebetsi e 'maloa ea enzymatic. Ho feta moo, sekhahla sa tšebeliso se lula se sa reroa ho latela tekanyo ea tlhahiso.

Ntho e 'ngoe ea bohlokoa eo re lokelang ho e hlokomela ke hore, ho fapana le kalafo tse ngata tse khahlanong le botsofali tse u sieang matšoao a sa foleng. Litla-morao tsa NMN haufi le null. Ntumelle hore ke hlakise hore na NMN e ama bophelo ba hau joang.

 

Nikotinamide Mononucleotide (NMN) ke eng?

Nicotinamide Mononucleotide (Nmn) phofo (1094-61-7e tsoa ho niacin. Ke sehlahisoa se tsoang karabong lipakeng tsa nicotinamide ribose le sehlopha sa phosphate. Motsoako ona o bapala karolo ea bohlokoa ho biosynthesis ea NAD + (nicotinamide adenine dinucleotide), e bohlokoa haholo mesebetsing ea lisele tsa biochemical.

Ha NAD + e kopantsoe, Nicotinamide Mononucleotide phofo e ngata e sebetsa e le substrate bakeng sa nicotinamide mononucleotide adenylyltransferase, e leng enzyme e ikarabellang bakeng sa ho e fetisetsa ho NAD +.

NMN ke e 'ngoe ea mehloli ea bohlokoa ea matla a mobile ka har'a' mele oa motho. Kaha ke selelekela sa NAD +, ho theoha ha motsoako o mong ho tla ama e mong haholo.

Liphuputsong tsa morao-rao tsa bophelo ba morao-rao, Nicotinamide Mononucleotide e netefalitse hore ke ea mantlha sebakeng sa kalafo. Phetoho e 'ngoe e ikhethang e bile ho hlokomela karolo e kholo ea setsi seo sa ho khutlisa boitemoaro le ho khutlisa botsofaling.

Haufinyane, ho na le lipatlisiso tse ts'episang mabapi le taolo ea mofetše oa nicotinamide mononucleotide.

 

Lijo tse nang le Nicotinamide Mononucleotide (NMN)

• Broccoli
• Lik'habeche
• Edamame
• Mushroom
• tamati
• Avocado
• Komokomore
• Shrimp
• Khomo ea nama ea nama e tala

 

Melemo ea Nicotinamide Mononucleotide (NMN) ke efe?

Tlatsetso ea ho tsofala

U tla lumellana le 'na hore botsofali le moriri o moputsoa li tsamaisana le bohlale. Leha ho le joalo, thabo ea kholo ena e phela ha nakoana ha u qala ho ba le linako tse phahameng. Ha re tsofala lilemong tsa rona, 'mele ea rona e fetoha leseli la maloetse.

Boloetse bo siea tšusumetso e kholo ts'ebetsong ea cellular. Mohlala, maemo a NAD + le Nikotinamide Mononucleotide haholo a theoha nakong ea lilemo tsa khauta. Le ha 'mele o ntse o kopanya lik'hemik'hale, sesebelisoa sa tšebeliso e feta haholo maqhubu a ntlafatso.

Tabeng ea tšenyo ea DNA, NAD + e kenya tšebetsong PARP1, protheine e lokisa DNA, ho khutlisetsa litho tse amehang.

Ho fokotseha ha NMN ho ama maemo a NAD + 'me hamorao ho lebisa ho fokotseha ha tlhahiso ea matla ke mitochondria.

Liphuputso tse entsoeng ke Dr. Sinclair, setsebi sa lefutso sa Univesithi ea Havard, se tiisa bokhoni ba nicotinamide mononucleotide supplement ho fokotsa botsofali. Setsebi se lumela hore eena le ntate oa hae ba nka tlatsetso mme ka sebele e ntlafatsa mohopolo le ho chorisa likelello tsa bona.

 

Phekolo ea lefu la tsoekere II

Ho theoha ha nicotinamide adenine dinucleotide ho ka baka lefu la tsoekere la mofuta oa II.

Ho tsamaisa Nicotinamide Mononucleotide ho ka ntlafatsa haholo mamello ea tsoekere le kutloisiso ea insulin ho bakuli ba nang le lefu la tsoekere. Ntle le moo, bo-ramahlale ba bang ba ne ba bolela hore kalafo e fetola mofuta oa liphatsa tsa lefutso o bakoang ke phepo e mafura haholo.

 

 

neuroprotection

Ha maemo a nicotinamide adenine dinucleotide a theoha, boemo ba kelello bo kotsing.

Tsamaiso ea NMN e ntlafatsa bongata ba NAD +, ka hona, ho sireletsa boko hore bo se ke ba senyeha. Ka bokhutšoanyane, Nikotinamide Mononucleotide e thusa ka tšebetso ea methapo le kutloisiso, ho kenyelletsa le ho ithuta le ho hopola.

Ka lebaka lena, kalafo e sebelisetsoa ho laola lefu la Alzheimer's, Parkinson's syndrome, 'dementia'.

Phuputso e 'ngoe e tiisa se boletsoeng ka holimo melemo ea nicotinamide mononucleotide ka ho netefatsa hore tlatsetso e sebetsana hantle le ts'enyo ea intracerebral. Ha bafuputsi ba tsamaisa lethal dose litoeba tsa khale, lithuto li ngolisitse ntlafatso e kholo tlhahisong ea intracerebral NAD +. Ka lebaka leo, ho bile le phokotso e ileng ea latela ea ho ba le ischemic stroke le ho ruruha ha methapo.

 

Metabolism e ntlafalitsoeng

Boemo ba Optimum NMN 'meleng bo fetolela keketseho ea NAD +, e laolang mesebetsi ea matla a matla, tokiso ea DNA le karabelo ea khatello ea maikutlo. Ho tloha ka Nicotinamide Mononucleotide e ama metabolism ka kotloloho, khaello ea eona e ka baka maemo a 'maloa a ts'ebetsong joalo ka botenya, lefu la tsoekere, sebete se mafura le dyslipidemia.

Tabeng ea ho se mamellane ha tsoekere, NMN e nka bohato ba ho ntlafatsa tsoekere ea tsoekere.

Patlisiso e tiisa hore u ka lahleheloa ke ho fihla ho 10% ea boima ba 'mele oa hau haeba u nka NMN. Joalokaha Dr. Sinclair a beha, tšusumetso ea tekanyetso e le 'ngoe ea NMN bakeng sa batho e lekana le ho oela fatše.

 

Ho Matlafatsa Bocha

Lebala ka lithane tsa lisebelisoa tsa litlolo le ho buuoa sefahleho tse u sieang lihloho tse sa fetoleheng.

Joalokaha bo-ramahlale ba beha, re tsofetse joaloka methapo ea rona ea methapo. Ka polelo ena, o ka hlakisa hore ho khutlisetsa matla a methapo ea methapo le methapo ea kutlo ea methapo ea mali e tla bapala ka boqhekanyetsi bophelong ba rona.

Se khethollang bocha ho botsofali ke ho ba mafolofolo le ho mamella mesifa. Le ha litšobotsi tsena tsohle li ntlafala ka ho ikoetlisa khafetsa, senescence e nyenyefatsa mathata le mesifa ea mesifa ea fokola ha phallo ea mali e fokotseha ka har'a lits'ebetso tsena.

Ntumelle ke hlalose ho latela pono ea mahlale. Ha lisele tsa endothelial tsa motho li fokotseha ka liprotheine tsa Sirtuin1, phallo ea mali e tla putlama haholo. U lokela ho utloisisa hore NMN ke molaoli oa bohlokoa oa SIRT1. Ka hona, ho tsamaisa tlatsetso ena ho tla kenya tšebetsong Sirtuin-signaling, e tla hlahisa li-capillaries tse ncha ho fana ka oksijene le limatlafatsi mesifa le litho tse ling tsa bohlokoa.

 

NMN vs NR

Joale, ke eng eo e buang ka nicotinamide mononucleotide vs riboside?

Che, ka bobeli ke baetapele ba NAD +.

Ho sheba mekhatlo ea bona ea lik'hemik'hale ho tla u joetsa hore NMN e na le boholo ba molek'hule ho feta NR. Kahoo, nicotinamide riboside e ka e etsa ka 'mele oa motho ntle le tlhoko ea ho senya molek'hule eohle ea eona.

Leha ho le joalo, ho na le tlhase ea tšepo ha phuputso ea morao-rao e netefalitse hore ho na le transporter e makatsang e lumellang khemikhale ho feta ts'ebetsong ea tšilo ea lijo. Boithuto ba pejana bo felisitse monyetla ona ho fihlela bo-rasaense ba bang ba sibolla protheine ea Scl12a8, e thusang ho fetoloa ha NMN ho nicotinamide adenine dinucleotide.

Boholo ba basebelisi ba fumana nicotinamide mononucleotide theko e phahame hanyane ho feta ea mphato oa eona oa riboside.

 

Patlisiso ea Nicotinamide Mononucleotide (NMN)

Le ha ho na le lithuto tse ngata tse ngata tsa boithuto le tse matla Tlhahlobo ea tlatsetso ea NMN ho tloha ha e sibolloa ka 1963, ka kopo ntumelle ho bua ka merero e hlokomelehang.

 

NMN e Matlafatsa Bocha

Ho tloha 2013, Dr. Sinclair o nkile karolo ka mafolofolo ho ithuteng Nicotinamide Mononucleotide tlatsetso le karolo ea eona e le tlatsetso e khahlanong le botsofali. Leqepheng la hae la lipatlisiso, setsebi sa liphatsa tsa lefutso se hlokometse hore kalafo e ntlafalitse matla a mesifa le metabolism ea mefuta ea litoeba. Dr. Sinclair o bapisitse ts'ebetso ea NMN le ho sebetsa.

Ka lipatlisiso, genetic ena ea Harvard ha e tlalehe litla-morao tsa NMN tse tlatsetsang.

 

Karolo e sireletsang ea Cardio ea NMN

Patlisisong ea tlatsetso ea NMN ea 2014, Yamamoto le metsoalle ea hae ba ikemiselitse hore NMN e na le thepa e sireletsang Cardio. Ho tsamaisa tlatsetso ho tla sireletsa pelo ho tsoa reperfusion le likotsi tsa ischemic.

Lilemo tse peli hamorao, De Picciotto le bo-mphato ba hae ba liphatsa tsa lefutso ba fumane hore NMN e ka khothaletsa tšebetso ea methapo.

 

NMN e loantša Neurodegeneration

Ka 2015, Long le moifo oa hae ba hlokometse hore tlatsetso ea NMN e ka phekola Alzheimer's le ho fokotsa matšoao a eona a mabe. Selemo hamorao, Wang le sehlopha sa hae sa bo-ramahlale ba ile ba fihlela qeto ea hore kalafo e tla loants'etsa mafu a kelello le ho senyeha hoa methapo ea kutlo.

Lilemong tse latelang, bo-rasaense ba tlatsetso ba NMN ba tlil'o ts'ehetsa katleho ea Nicotinamide Mononucleotide ho ntlafatsa ts'ebetso ea ts'ebetso.

 

NMN e Ntlafatsa Mesebetsi ea 'mele le ea immunological

Ka 2013, Mills le sehlopha sa hae ba ile ba fumana hore nicotinamide mononucleotide (NMN) e ka khona ho sebetsana le lefu la tsoekere la mofuta oa II. Lilemo tse tharo hamorao, o ile a tiisa hore tlatsetso e bala ho fokotseha ha 'mele le boits'oaro ba' mele ho litoeba tsa khale. Selemong sona seo, Mills o ile a ikopanya le Yoshino le Imai ho ithuta hore na NMN e ama vascularity le karolo ea eona joang khatello ea mali.

 

Transporter e makatsang ea NMN

Imai le sehlopha sa litsebi tsa biochemists ba fumane Slc12a8, e thusang ho kenngoeng ha Nicotinamide Mononucleotide 'meleng. Ts'ebetso e potlakile ebile e tla ama bosholu ba NMN.

 

Litlhahlobo tsa meriana

Ho tloha ka selemo sa 2017, Litsebi tsa thuto ea thuto tse tsoang Keio (Tokyo) le liunivesithi tsa Washington li nkile karolo ka mafolofolo litekong tsa bongaka tsa NMN har'a liithuti tse tsofetseng empa li phetse hantle.

Morero oa liteko tsena tsa motho ke ho theha polokeho ea nicotinamide mononucleotide le ho utloisisa hore na tlatsetso e ama mesebetsi ea beta-cell joang. Ntle le moo, bo-rasaense ba lipatlisiso ba batlile ho tseba hore na ho na le ba neng ba le teng Litlamorao tse tlatselletsang tsa NMN.

 

Mofuta oa Nicotinamide Mononucleotide (NMN)

Mohlomong potso e tlang kelellong ea hau ke hore, "Ke lokela ho nka bokae NMN?" Joale, e re ke u phehelle.

Tekanyetso e tloaelehileng ea NMN bakeng sa batho e ka ba 25mg le 300mg ka letsatsi. Litekong tsohle tse fumanehang tsa kliniki, lithuto li ka nka boholo ba 250mg / letsatsi.

Ngaka Sinclair o ipolela hore o nka 750mg ea NMN ka letsatsi. Haeba u rera ho lekola tlhahlobo ea tlatsetso ea NMN ea marang-rang, u tla hlokomela hore basebelisi ba bang ba nyolohela ho 1000mg / ka letsatsi. Le ha ho se na litlaleho tse tsebahalang tsa litla-morao tsa nicotinamide mononucleotide, o lokela ho khomarela lethal dose le tlase ka moo ho ka khonehang.

 

 

Na Nikotinamide Mononucleotide (NMN) E Sireletsehile

Ho fihlela joale, ha ho na data ea ho qosa Nicotinamide Mononucleotide e sa bolokeha. Ho tsoa lirekotong tse phatlalalitsoeng nakong ea liteko tsa bongaka, ha ho sehlooho se neng se ngolisitse litla-morao tsa nicotinamide mononucleotide. Ho feta moo lithuto tsa pele ho nako li atlehile ntle le ho rekota matšoao afe kapa afe a bohloko.

 

Tlatsetso ea Nicotinamide Mononucleotide (NMN)

Kaha nicotinamide mononucleotide ha e so fumane tumello e felletseng ke FDA, e ke ke ea ba sethethefatsi sa ngaka. Leha ho le joalo, o ka e nka e le lijo tse eketsehileng.

Le ha o ka e fumana mabenkeleng a lehae a lithethefatsi, sebaka se loketseng sa ho reka sehlahisoa se fumaneha marang-rang. U ka reka phofo ea nicotinamide mononucleotide ka bongata bakeng sa lipatlisiso tsa hau kapa ua batla tlatsetso ea phepo. Leha ho le joalo, etsa bonnete ba hore o reka ho mofani oa thepa ea beta-nicotinamide mononucleotide.

Ho eketsa bioavailability ea NMN, o lokela ho khetha lipilisi tse tlase ho fapana le lipilisi tsa molomo.

Ho ea ka litekanyetso tsa FDA, motho o hloka bonyane 560mg ea Nicotinamide Mononucleotide ka letsatsi. Seo u lokelang ho se tseba ke hore broccoli le hop li ingolisa NMN e ngata haholo ha li bapisoa le lijo le litholoana tse ling.

Mohlala, broccoli e na le lipakeng tsa 0.25mg le 1.12mg ea k'hemik'hale. Kahoo, haeba u batla ho boloka boemo bo phetseng hantle 'me u latela litlhoko tsa FDA, u tla tlameha ho ja liponto tse 1500 tsa broccoli ka letsatsi. Kaha ho etsa joalo ho thata haholo, o lokela ho khetha ho reka tlatsetso ho mofani oa beta-nicotinamide mononucleotide.

 

 

References:

• Yao, Z., et al. (2017). Nicotinamide Mononucleotide e Thibela Ts'ebetso ea JNK ho Fokotsa Mafu a Alzheimer.
• Yoshino, J., et al. (2011). Nicotinamide Mononucleotide, Key NAD (+) Intermediate, e tšoara Pathophysiology ea Lijo le Lefu la Tsoekere la Age ho Mice. Cell Metabolism.
• Yamamoto, T., et al. (2014). Nicotinamide Mononucleotide, Intermediate of NAD + Synthesis, E Sireletsa Pelo ho Ischemia le Reperfusion.
• Wang, Y., et al. (2018). NAD + Tlatsetso e tloaetse likarolo tsa bohlokoa tsa Alzheimer's le likarabo tsa Tšenyo ea DNA ho Model e Mocha ea AD e nang le Khaello ea Khalemelo ea DNA.
• Keisuke, O., et al. (2019). Litlamorao tsa Alctu NAD Metabolism ho Mathata a Metabolic. Tlaleho ea Saense ea Biomedical.

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