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Alpha-lipoic Acid phofo (1077-28-7)

Alpha-lipoic acid / thioctic acid phofo ke k'hemik'hale e kang vithamine e bitsoang antioxidant. Tomoso, sebete, liphio, spinach, broccoli le litapole ke mehloli e metle ea alpha-lipoic acid / thioctic acid. E boetse e etsoa ka laboratoring hore e sebelisoe e le moriana. Alpha-lipoic acid / thioctic acid e atisa ho nkoa ka molomo bakeng sa lefu la tsoekere le matšoao a amanang le methapo ea lefu la tsoekere ho kenyelletsa ho chesa, bohloko le ho shoeloa ke maoto le matsoho. E fuoa hape joalo ka ente ka methapong (ea IV) bakeng sa ts'ebeliso e tšoanang. Litekanyetso tse phahameng tsa alpha-lipoic acid / thioctic acid lia amoheloa Jeremane bakeng sa kalafo ea matšoao ana a amanang le methapo.

Etsa: Batch Production
sephutheloana: 1KG / mokotla, 25KG / moqomo
Wisepowder e na le bokhoni ba ho hlahisa le ho fana ka bongata bo boholo. Lihlahisoa tsohle tlasa boemo ba cGMP le sistimi e thata ea taolo ea boleng, litokomane tsohle tsa tlhahlobo le sampole e teng.
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Tlhahisoleseling ea motheo ea Alpha-lipoic Acid powder

 

lebitso Alpha-lipoic Acid phofo
CAS 1077-28-7
Ho hloeka 98%
Lebitso la k'hemik'hale (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -cy-Lipoic asiti
Li-synonyms DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; EA-628502-KS NSC 90788; Protogen A; Tioksane;
Molecular Formula C8H14O2S2
Boima ba 'mele 206.318 g / mol
Melting Point 60-62 ° C
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
foromo tiileng
Ponahalo Boreleli bo Botala ho Borena
Halofo ea bophelo Metsotso e 30 ho isa ho hora e le ngoe
Solubility Soluble ho Chloroform (Slightly), DMSO (Slightly), Methanol (Honyane)
Boemo Storage E omme, e lefifi ebile e le 0 - 4 C ka nako e khuts'oane (matsatsi ho isa ho libeke) kapa -20 C nako e telele (likhoeli ho isa ho lilemo).
kopo Motsoako o ntšang mafura.
Tokomane ea Teko fumaneha
Alpha-lipoic asiti
Setšoantšo sa phofo
Yellow Light

 

Alpha-lipoic Acid ke eng?

Alpha-lipoic acid ke antioxidant e tsoang ho caprylic acid. Mabitso a mang a eona ke ALA, lipoic acid, Biletan, Lipoicin, Thioctan, jj. Lebitso la eona la lik'hemik'hale ke 1,2-dithiolane-3-pentanoic acid kapa thioctic acid. Ke motsoako oa organosulfur mme o hlahisoa 'meleng oa batho le oa liphoofolo. Tlhahiso ea eona e hlaha ho octanoic acid le cysteine ​​joalo ka mohloli oa sebabole. Ke ntho ea bohlokoa bakeng sa metabolism ea aerobic 'meleng. E teng seleng e 'ngoe le e' ngoe 'me e thusa ho theha matla ho tsoa tsoekere.

E na le mesebetsi e mengata ea lisele le limolek'hule, ka lebaka la bokhoni ba eona ba antioxidant. Ketso ena ea antioxidant ea alpha-lipoic acid e hlahisitse thahasello ea eona ea ho sebelisoa e le tlatsetso ea phepo e nepahetseng. E boetse e sebelisoa e le moemeli oa kalafo. E kanna ea ba kalafo e ka bang teng ho lefu la tsoekere, ho fokotsa boima ba 'mele, neuropathy e bakoang ke lefu la tsoekere, pholiso ea leqeba, ho ntlafatsa maemo a letlalo, jj.

Alpha-lipoic acid e na le bophelo ba halofo ea metsotso e 30 hora e le 'ngoe. E qhibiliha hanyane ho chloroform, dimethyl sulfoxide (DMSO) le methanol. E ka fumanoa ho spinach, tomoso, broccoli, litapole, nama e kang sebete le liphio.

Tekanyo e phahameng eo motho e moholo a ka e nkang ka letsatsi ke 2400mg.

 

Alpha-lipoic Acid e Sebetsa Joang?

Alpha-lipoic acid e na le thepa ea antioxidant. E bolela hore e ka loants'a mafolofolo 'meleng le ho fokotsa liketsahalo tse kang botsofali ba sele le ho thusa ho boloka lisele tse phetseng hantle.

E hlahisoa mitochondria mme e sebetsa joalo ka cofactor ea bohlokoa bakeng sa ho senya li-enzyme le limatlafatsi. E boetse e chesa li-ion tsa tšepe ebile e fokotsa mofuta oa oxidized oa li-antioxidants tse ling tse kang vithamine C, Vitamin E le glutathione. Alpha-lipoic acid e ea hlokahala bakeng sa ho laola mefuta ea oksijene e sebetsang.

Alpha-lipoic acid e boetse e khothaletsa sistimi ea ts'ireletso ea antioxidant. E etsa sena ka polelo ea liphatsa tsa lefutso ea Nrf-2-mediated. E boetse e hlophisa liphatsa tsa lefutso tse hlokang sehlahisoa sa peroxisome ho li kenya tšebetsong.

Alpha-lipoic acid e boetse e thibela nyutlelie kappa B. E kenya tšebetsong protheine kinase (AMPK) e sebelisitsoeng ke AMP ka mesifa ea masapo mme e baka liketso tse fapaneng tsa metabolic.

Ho na le mefuta e 'meli ea alpha-lipoic acid. Ke oxidized lipoic acid (LA) mme e fokolitse dihydrolipoic acid (DHLA). DHLA e hlahisoa mitochondria e nang le lisele 'meleng. Sena se ka etsahala ka nicotinamide adenine dinucleotide hydrogen (NADH) le lipoamide dehydrogenase. Lintho tsena tse peli li thusa karabong ena ea phetoho.

Lisele tse hlokang mitochondria, alpha-lipoic acid e ka fokotsoa ho ba DHLA ka nicotinamide adenine dinucleotide phosphate (NADPH). Ketso ena e thusitsoe ke glutathione le thioredoxin reductases.

Alpha-lipoic acid e na le thepa e ikhethang e e etsang hore e fapane le glutathione. Le ha e le mofuta feela o fokolitsoeng oa glutathione o nang le antioxidant, mefuta e fokotsoang le e sa fokotsoang ea alpha-lipoic acid ke li-antioxidants tse matla.

Alpha-lipoic acid e boetse e kentse letsoho ho lokisa liprotheine tse nang le oxidized mme e ka thusa ho laoleng phetiso ea liphatsa tsa lefutso.

Alpha-lipoic acid e na le thepa e khahlanong le ho ruruha hape. E emisa kappa B kinase, e leng enzyme e etsang hore NF-kB e sebelise, e hlahisang cytokines e ruruhang [1].

 

Nalane ea Alpha-lipoic Acid

Alpha-lipoic acid e fumanoe ka 1937 ke Snell. Ka nako eo, bo-rasaense ba ne ba ithuta mofuta oa libaktheria tse sebelisang lero la litapole ho ikatisa. 1 ka 1951, e ne e arotsoe ke Reed. Tšebeliso ea pele ea bongaka e qalile Jeremane ka 1959 bakeng sa ho phekola chefo ka lebaka la li-mushroom tsa cap.

Tlhahisoleseling mabapi le ts'ebeliso ea alpha-lipoic acid le ts'ebetso ea eona ha e so phetheloe. Tšebeliso ea eona kalafong ea bongaka ha e so netefatsoe ke FDA. Empa ho theosa le lilemo, e fumane botumo e le tlatsetso.

 

Litla-morao tsa alpha-lipoic acid ke life?

Joalo ka meriana e meng e mengata, alpha-lipoic acid le eona e na le litla-morao.

Tse ling tsa litla-morao tse tloaelehileng tsa alpha-lipoic acid ke tsena:

  • Hlooho ea hlooho
  • Ho senya
  • Nausea
  • Ho otla
  • Hypersensitivity
  • Hlooho e khanyang
  • Serokere e tlaase ea mali
  • Rash ea letlalo
  • Ho kenella linthong tse ngata

Liphello tsa phofo ea alpha-lipoic acid ho bo-mme le ba anyesang ha li tsejoe. Kahoo ho kgothaletswa ho qoba ho sebelisa sena ha o le moimana kapa ha o anyesa.

 

Melemo ea Alpha-lipoic Acid ke efe?

Ho na le melemo e 'maloa ea alpha-lipoic acid. Ke:

 

Phello Mafu a Alzheimer's

Alpha-lipoic acid phofo e na le monyetla oa ho liehisa ho qala kapa ho fokotsa tsoelo-pele ea lefu la neurodegenerative. Phuputso e entsoe ho bakuli ba robong ba nang le lefu la Alzheimer's. 600mg ea alpha-lipoic acid e ne e fuoa letsatsi le letsatsi ka likhoeli tse 12 [2]. E ne e khona ho tsitsisa ts'oaetso ho bakuli bana. Thepa ea eona ea antioxidant e ka liehisa boemo mme e ka sebetsa joalo ka moemeli oa ts'ireletso ea methapo.

 

Phello ho lefu la tsoekere

Alpha-lipoic acid e ka thusa ho theola maemo a tsoekere maling ho bakuli ba nang le lefu la tsoekere. Kaha thepa ea eona ea antioxidant e ka tlosa li-radical mahala, e ka thusa ho sebetsana le tšenyo ea lisele tse bakoang ke lefu la tsoekere. E kanna ea ntlafatsa ho hanela insulin ha batho ba nang le lefu la tsoekere. E ka thibela lefu la lisele tsa beta mme e kanna ea ntlafatsa tsoekere le ho fokotsa mathata a lefu la tsoekere, haholo-holo lefu la tsoekere la lefu la tsoekere [3].

 

Phello ho Stroke

Alpha-lipoic acid e na le bokhoni ba ho itšireletsa. Liketso tsa eona tsa antioxidant li ka thusa le ho ata ha neuron bokong bo nang le stroke. Phuputso e entsoeng ka likhoto tse nang le leqeba la ischemic tse fuoeng alpha-lipoic acid li bontšitse ntlafatso maemong a tsona [4]. Kahoo, ho ka thusa ho ntlafatsa maemo a bakuli ba setorouku.

 

Phello ea ho tsofala

Alpha-lipoic acid phofo le eona e ka thusa ho fokotsa botsofali ba letlalo. Alpha-lipoic acid e ka fana ka elektrone e le 'ngoe ho sesebelisoa se sebetsang se ka senyang letlalo le ho tsofala le ho itšilafatsa. Ka tsela ena e ka emisa ho tsofala hape e ka tlatsa karolo ea karolo e haelloang ea antioxidant [5]. Sena se ka thusa hape khahlanong le tšenyo e bakiloeng ke lintho tse fapaneng.

 

Phello ho Chefo ea Mercury le Autism

Alpha-lipoic acid e ka fetisa tšitiso ea mali le bokong. E kanna ea sebelisoa ho hlakola mercury e hoketsoeng liseleng tsa boko haeba ho ka ba le chefo ea mercury [6]. E ka bokella mercury e tlameletsoeng maling ho tloha moo mahlahana a mang a chelator a kang dimercaptosuccinic acid (DMSA) kapa methylsulfonylmethane (MSM) a ka fetisang mercury ka mokhoa o sireletsehileng liphio ebe a ntšetsoa ka ntle ho moroto. Kaha ha ho na DMSA kapa MSM e ka tšelang tšitiso ea mali le bokong, ho sebelisa alpha-lipoic acid le DMSA ho ka thusa ho tlosa mercury ka polokeho. Sena se ka thusa ho sebetsana le autism joalo ka ha bana ba autistic ba na le litekanyetso tse phahameng tsa mercury bokong ba bona ha li bapisoa le tse tloaelehileng. Leha ho le joalo, lithuto tse mabapi le sena li na le moeli.

 

Phello ea Phokolo ea mali

Ho ile ha etsoa phuputso ho bakuli ba nang le lefu la liphio la ho qetela le nang le phokolo ea mali moo alpha-lipoic acid e fuoeng bakuli [7]. E bontšitse e le matla joaloka erythropoietin ka ho eketsa maemo a hemoglobin ntle le litlamorao tse mpe. Kahoo, e ka thusa ho phekola phokolo ea mali e bakoang ke ho hloleha ha renal qetellong. E kanna ea ba ea ruisa moruo.

 

Phello e le Antioxidant

Kaha alpha-lipoic acid phofo ke antioxidant, e na le melemo e mengata mme e ka thusa ka mefuta e mengata ea maemo 'meleng.

 

Phello ho Neurotoxicity ka lebaka la Tahi

Joala bo ka baka mathata a methapo ka lebaka la khatello ea mali. Alpha-lipoic acid e ka thusa ho phekola methapo ea kutlo ka lebaka la joala. E ka thibela protheine oxidation e hlahang ts'ebetsong ea ethanol [8].

 

Phello ea ho Lahleheloa ke Boima ba 'mele

Alpha-lipoic acid e kanna ea ba tlatsetso e loketseng bakeng sa ho thusa ho theola boima ba 'mele bakeng sa batho ba batenya ho tlola tekano le ba batenya ho tlola [9]. E na le litla-morao tse fokolang ha e bapisoa le meriana e meng ea tahlehelo ea boima 'me e na le li-antioxidants tse ka thusang ho boloka motho a phetse hantle.

 

Litlhōlisano

Ha ho na lithuto tse ngata mabapi le li-contraindication tsa alpha-lipoic acid. Leha ho le joalo, bakuli ba bang ba nang le maemo a itseng ba tlameha ho ba hlokolosi pele ba sebelisa ntho ena mme ba bone ngaka pele ba e sebelisa.

Tse ling tsa maemo ana ke:

  • Lefu la sebete
  • Ho noa joala haholo
  • Boloetse ba qoqotho
  • Khaello ea thiamine

 

Likamano tsa lithethefatsi le Alpha-lipoic Acid

Ha ho na tlhahisoleseling e ngata mabapi le tšebelisano ea alpha-lipoic acid le lithethefatsi tse ling. Empa meriana e meng e molemo ho qojoa ka tlatsetso ena.

Tse ling tsa lithethefatsi tsena ke:

Lithethefatsi tsa Hypoglycemic - Alpha-lipoic e na le bokhoni ba ho fokotsa tsoekere maling. Maemong a mang e ka baka insulin autoimmune syndrome, e lebisang ho hypoglycemia. Kahoo ho e sebelisa ka lithethefatsi tsa hypoglycemic ho ka baka hypoglycemia e potlakileng e ka bang kotsi.

Meriana ea qoqotho - Alpha-lipoic acid e ka theola boemo ba lihormone tsa qoqotho. Kahoo ho hlokahala tlhokomelo e nepahetseng ha e sebelisoa levothyroxine.

 

U ka reka alpha-lipoic acid hokae ka 2021?

U ka reka phofo ea alpha-lipoic acid ka kotloloho ho tsoa ho k'hamphani ea moetsi oa alpha-lipoic acid. E fumaneha ka phofo e bosehla bo bosehla ho isa bosehla. E pakiloe ka har'a sephutheloana sa 1 kg ka pakete le 25kg ka moqomo. Leha ho le joalo, sena se ka fetoloa ho latela litlhoko tsa moreki.

E hloka ho bolokoa ka mocheso oa 0 ho isa ho 4 ° C bakeng sa nako e khuts'oane le -20 ° C bakeng sa nako e telele. E hloka sebaka se batang, se lefifi le se ommeng bakeng sa polokelo ho e thibela ho arabela ka lik'hemik'hale tse ling tikolohong. Sehlahisoa sena se entsoe ka metsoako e metle ka ho fetisisa ho latela melaoana e nepahetseng.

 

Litemana tse boletsoeng

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alpha-lipoic acid e na le litlamorao tse khahlano le ho ruruha ho lisele tsa mesangial tse khothalelitsoeng ke lipopolysaccharide ka ho thibela tsela ea ho tšoaea ea nyutlelie kappa B (NF-κB). Ho ruruha, 38(2), 510-519.
  2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid e le mokhoa o mocha oa kalafo bakeng sa lefu la Alzheimer-Tlhahlobo ea tlhahlobo ea likhoeli tse 48. Ka Mathata a Neuropsychiatric Tsela e Kopanetsoeng(maq. 189-193). Springer, Vienna.
  3. Laher, I. (2011). Lefu la tsoekere le alpha-lipoic acid. Frontiers ho pharmacology, 2, 69.
  4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Phekolo ea alpha-lipoic acid e matlafatsa kelello ebile e khothaletsa ho fola ka mor'a ho otloa ke likhoto. Boko ba limolek'hule, 8(1), 1-16.
  5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Phello ea α-Lipoic Acid ho Nts'etsopele ea Letlalo la Batho le Tšoanang le Ho Sebelisa Model Pumpin-on-a-Chip Model. International Journal of Scientific Sciences, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Tsebo ea alpha-lipoic le dihydrolipoic acid e le tse ts'episang batho ba nang le khatello ea mali le ba ka bang chelator ho mercury toxicology. Tlaleho ea biochemistry e sa tloaelehang, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Karolo ea alpha-lipoic acid taolong ea phokolo ea mali ho bakuli ba nang le ts'oaetso e sa foleng ea renal ba fetang ho hemodialysis. Koranta ea machabeng ea nephrology le lefu la renovascular, 6, 161.
  8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alpha-lipoic acid e thibela protheine e kenang ka har'a ethanol liseleng tsa hippocampal HT22. Li-Letters tsa Neuroscience, 328(2), 93-96.
  9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha ‐ lipoic acid (ALA) e le tlatsetso bakeng sa tahlehelo ea boima ba 'mele: sephetho sa tlhahlobo ea meta ea liteko tse laoloang ka tatellano. Tlhahlobo ea botenya, 18(5), 594-601.

 

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